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While Zepbound does not typically cause this, the general stress on the nervous system during weight loss can make these sensations more noticeable

Addition of the GLP-1 receptor antagonist Ex9 to perfused Gcgr / or control pancreases reduced glucose-stimulated secretion of somatostatin, and administration of Ex-9 to perfused Gcgr / pancreases abolished all increments in somatostatin secretion

Legrand-Abravanel F, Claudinon J, Nicot F, Dubois M, Chapuy-Regaud S, Sandres-Saune K, Pasquier C, Izopet J